ea0088001 | Abstracts | BES2022
de Brachene Alexandra Coomans
, Corentin Scoubeau
, Anyishai E Musuaya
, Angela Castela
, Julie Carpentier
, Vitalie Faoro
, Malgorzata Klass
, Miriam Cnop
, Decio L Eizirik
Aim of the work: Diabetes is characterized by progressive loss of functional pancreatic beta cells. None of the therapeutic agents used to treat diabetes arrest this process and preventing beta cell loss remains a major unmet need. We have previously shown that serum from 8 young healthy males who exercised for 8 weeks protects human islets and human insulin-producing EndoC-βH1 cells from apoptosis induced by pro-inflammatory cytokines or the endoplasmic reticulum (ER) st...